肽核酸(PNA)miRNA 抑制剂
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介绍
凭借 肽核酸(PNA) 的独特优势,PNA miRNA 抑制剂在特异性和稳定性方面远胜于现有的 miRNA 抑制剂。这些单链 PNA 是研究 miRNA 功能的绝佳工具,通过特异性结合内源性 miRNA,有效抑制其功能。
此外,PNA miRNA 抑制剂结合了 CPP(细胞穿透肽),不仅提升了转染效率,甚至在某些细胞类型中无需转染试剂即可实现穿透。
产品名称 | 规格 |
PNA miRNA inhibitor, miRNA-specific | 25 nmole |
PNA miRNA inhibitor, Negative Control | 25 nmole |
PNA miRNA inhibitor, miRNA-specific & Fluorescein-labeled | 5 nmole |
PNA miRNA inhibitor, Negative Control & Fluorescein-labeled | 5 nmole |
特点
有效抑制 miRNA 的活性
对细胞无毒性
通过对抗酶稳定性,实现持久的抑制效果
通过 CPP(细胞穿透肽)改善细胞渗透性
精选引用
想了解使用我们的PNA已发表的研究文献吗?
Exponential Increase in an Ionic Signal: A Dominant Role of the Space Charge Effect on the Outer Surface of Nanochannels
Anal. Chem. | 28 Sep 2021 | DOI: https://doi.org/10.1021/acs.analchem.1c03431
All single-stranded PNA sequences were purchased from SBS Genetech Co., Ltd. (Beijing, China).
Peptide Nucleic Acid-Functionalized Nanochannel Biosensor for the Highly Sensitive Detection of Tumor Exosomal MicroRNA
Anal. Chem. | 30 July 2021 | DOI: https://doi.org/10.1021/acs.analchem.1c01898
PNA was synthesized by SBS Genetech Co. Ltd. (Beijing, China). Table S1 shows the above-mentioned oligonucleotide sequence. Sodium hydroxide (NaOH), formic acid (HCOOH), and other chemical reagents were obtained from Sinopharm Chemical Reagent Co. Ltd. (Shanghai, China).
Ultrasensitive Exosomal MicroRNA Detection with a Supercharged DNA Framework Nanolabel
Anal. Chem. | 2 April 2021 | DOI: https://doi.org/10.1021/acs.analchem.1c00295
Thiolated PNA with a−(CH2)6− spacer at the 5′ end was synthesized and purified by SBS Genetech Co., Ltd. (Beijing, China). All the sequences
are shown in Table S1.
仅用于研究,不用于治疗人类或动物
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